NUTRITION WINDOW: Parkinsons helped by caffeine

By Dr Michael Greger

Caffeine consumption appears to help prevent Parkinson’s, but what if you already have the condition?

A recent study found that giving folks the equivalent of about two cups of coffee a day worth of caffeine significantly improved symptoms of the disease. Of course, there’s only so much you can charge for coffee, so drug companies took caffeine and added a few side groups so they could patent it into new drugs (Preladenant and Istradefylline).

These drugs appear to work no better than plain caffeine, which is dramatically cheaper and probably safer.

Similarly, certain plants, such as berries, and plant-based diets in general may help prevent Parkinson’s. This may be partially because of pollutants that magnify up the food chain into the meat and dairy supply, but it could also be from the protective phytonutrients in healthy plant foods. For example, as you can see in my 3-min video Treating Parkinson’s Disease With Diet, I profile a case report in which a dietician struck with Parkinson’s was able to successfully clear most of her symptoms with a plant-based diet rich in strawberries, whole wheat, and brown rice. These are rich sources of two particular phytonutrients, N-hexacosanol and fisetin, but there hadn’t been a formal interventional trial published, until now.
At its root, Parkinson’s is a dopamine deficiency disease due to a die-off of dopamine-generating cells in the brain. These cells make dopamine from L-dopa derived from an amino acid in our diet. The consumption of animal products blocks the transport of L-dopa into the brain, crowding it out. With this knowledge, researchers first tried what’s called a “protein redistribution diet.” This is where people could only eat meat for supper so the patients would hopefully be sleeping by the time the negative effects of the animal protein hit.
The researchers didn’t consider cutting out all animal products altogether until it was discovered that fiber consumption naturally boosts L-dopa levels. Thus, a plant-based diet would be expected to raise levodopa bioavailability and bring some advantages in the management of the disease through two mechanisms: reduced animal protein intake and an increased fiber intake. That’s why plant protein is superior, because that’s where fiber is found. So researchers put folks on a strictly vegan diet, saving beans for the end of the day, and indeed found a significant improvement in symptoms.

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